CONTRAVE®

CONTRAVE® for Weight Loss

CONTRAVE® is a prescription-only, FDA-approved weight-loss pill believed to work on two areas of your brain—the hunger center and the reward system—to reduce hunger and help control cravings.  CONTRAVE contains two medicines, bupropion and naltrexone. These well-known drugs have been prescribed separately for years—bupropion for depression and smoking cessation, and naltrexone for alcohol and opioid dependence.

Hypothalamus (hunger center) to Reduce Hunger

CONTRAVE® has a well-studied safety and tolerability profile. Three long-term (56 weeks) studies have shown that patients who add CONTRAVE lose approximately 2 to 4 times more weight than with diet and exercise alone. In one study, patients who also participated in an intensive diet and exercise program and remained on CONTRAVE for a full year, lost 25 pounds on average.

Benefits of CONTRAVE®

CONTRAVE may help patients make long-term changes to their eating behavior, lose weight, and keep it off. Across three long-term studies, patients taking CONTRAVE lost approximately 2-4x more weight than with diet and exercise alone. In one study, patients who stayed on CONTRAVE for a full year and participated in intensive behavior modification lost 25 pounds on average. For people who started with a BMI 30 to 35, more than 70% of those who saw results at Week 16 and remained on treatment for 56 weeks were able to move into a healthier, non-obese category (BMI 29.9 or less) after 1 year on CONTRAVE.